Sunday, December 29, 2019

The Technological Advances Of The Great Gatsby - 3475 Words

1. Introduction Ever since the fall we have not been unable to physically restore our glorious Eden experience, nor could we fix the mistake that Adam started with either good living or hard work. No council could be gathered; no theologian could negotiate his or her way out of our deserving judgment. We were indebted with sin, unable to choose right from wrong. God’s creation was just running around since birth with no clue as to who are or what was if any power was in us. We are like blind sheep aimlessly moving about with no direction, guidance or supervision. But is that the case? Are we helplessly wrapped in flesh and â€Å"totally depraved† as normal human beings? Depraved seems like such a solemn condition for such a sophisticated race of people who have achieved so many great things. Consider the technological advances we have accomplished, such as moving from horse driven wagons to electric powered cars or only communicating via close proximity to communicating via cell phones and email. There was a time when all people lived in tents or makeshift homes, however, now were capable of erecting buildings hundreds of stories in the air. Was God, not apart of this? Did He not use these people? Was He not aware of our abilities before we were conceived? The depraved state of humans would suggest we are in some parts incapable of good. How could one be total depraved, without hope, and still able to do all these things? Nevertheless, some would think that depravity means weShow MoreRelatedThe Great Gatsby By F. Scott Fitzgerald1271 Words   |  6 PagesAmerican Dream Essay By: Mary C. Watts In his novel,The Great Gatsby, F. Scott Fitzgerald attempted to explore the American Dream during a corrupt period of the 20’s. In this novel, he wants us to believe that money makes the world go round, or perhaps gets one headed in the right direction. Is it true that an individual can achieve success in life, regardless of family history or social status, if they work hard? Fitzgerald wanted to show the hidden boundaries dividing reality from illusionRead MoreThe Great Gatsby And The American Dream Essay791 Words   |  4 PagesAmerican culture has evolved into a faster communicating, better educated, and fast-paced culture. American culture is going to evolve into where we will barely talk in person and it will be less natural to talk face-to-face because of the many technological advances. As the future progresses, the â€Å"American Dream† begins to fade. In the â€Å"American Dream† it is stated that there should be â€Å"prosperity and success, as well as an upward social mobility for the family and children†. Yes, technology is makingRead MoreThe New Women Of The Great Gatsby By F. Scott Fitzgerald1230 Words   |  5 Pageshome, they were making breakthroughs in society that were unheard of. The 1920’s was a time for women reinvent themselves, and this was portrayed by the female characters in the novel, The Great Gatsby, by F. Scott Fitzgerald. During the time of the â€Å"Roaring Twenties,† there were a lot of technological advances as well as more career opportunities for women. In her article, â€Å"A New Women,† Louise Benner explains about how vacuum cleaners, irons, and washing machines were the most popular devices,Read MoreThe Great Gatsby and The American Dream of the 1920’s525 Words   |  2 Pagesattaining success, Jay Gatsby of F. Scott Fitzgerald’s The Great Gatsby by all appearances achieved the American Dream. If success is equal to materialism, then Gatsby was indeed successful. He used his display of wealth and possessions to gain the approval of his true love Daisy Buchanan. Some would argue, however, that this does not represent the American Dream accurately, but is a warning of how materialism can lead to the downfall of individuals and societies. â€Å"The Great Gatsby proves to be of bothRead MoreThe Impact of Hollywood in American Society1568 Words   |  6 Pagesvitasc ope and presented the first motion pictures on the public screen in the United States. (SOURCE) This was the great start of Hollywood. Many extraordinary producers and filmmakers began moving to Hollywood to seize this opportunity. With a new and improved invention of the kinetoscope, they no longer had copyright problems because of Thomas Edison and could finally bring their great films to life. The movies attracted audiences of groundbreaking size, due to convenient schedules, lowRead MoreThe Great Gatsby By F. Scott Fitzgerald1476 Words   |  6 Pageson in The Great Gatsby with this thought provoking quote. Not all people are born with the same advantages as others. There are many factors that have held people back from attaining their goals in our great country.. Despite the perception that Americans can move from rags to riches to live the American Dream, the trials and obstacles that underserved and minorities have to overcome reveals that the American Dream is a false hope. The lower class citizens do not have the access to great schools,Read MoreThe American Dream : The New World As A Land Of Opportunity For Social Mobility1457 Words   |  6 Pagessocial standard. The â€Å"American Dream† prevailed on the basis that â€Å"all men are equal† as the opportunity to pursue prosperity and achieve a higher social class became a reality for many of those who emigrated for social mobility. However, as technological advances assist in generating more profit, the economic gap between the wealthy and poor widens, often due to the wealthy’s exertion of power over and exploitation of the poor. As a result, the American Dream slowly becomes less accessible to the lowerRead Moreâ€Å"the Great Gatsby Is a Story of Infatuation and Disenchantment†. How Far and in What Ways Do You Agree with This View of the Great Gatsby and One Other Novel You Have Read.2179 Words   |  9 Pagesâ€Å"The Great Gatsby is a story of infatuation and disen chantment†. How far and in what ways do you agree with this view of The Great Gatsby and one other novel you have read. The Great Gatsby is a novel that, superficially, seems like the tragic story of infatuation and misunderstanding. However, set in 1920s America, it can be read in a number of different ways. This post-war period was a time of economic boom and rapid change in technological advances led to fashionable, more affluent and carefreeRead MoreWomens Rights In The 1920s Essay1018 Words   |  5 PagesThe 1920s brought many positive changes that are important to Canadian history. This era started the advances of women’s rights, entertainment, and technology. The innovations they started have contributed to the 21st century. The breakthroughs they made have continued to develop, and will further expand in the future. The 1920s began the uphill battle for womens rights within politics, personal life, and education. Up until the 1920s women weren’t allowed to vote. They pressed for the NineteenthRead MoreHistory Writing : The Roaring Twenties2067 Words   |  9 PagesNicolette Johnston Mr. Boardman History Writing Lab Period 6 January 8, 2015 WA #4 The 1920s, also known as the â€Å"Roaring Twenties†, was a time period of great prosperity. During the 1920s, major changes occurred. The Twenties marked the start of a new lifestyle for the world, in which styles such as appearances were different, the system of money changed, and things were viewed much differently than they were in past generations. There was a major shift in living conditions

Saturday, December 21, 2019

Cyber Insurance Case Study - 1428 Words

Introduction: Data is the new gold and insuring data is the new billion-dollar line of business. Data protection methods aren’t unbreakable; they merely act as a deterrent for hackers. For disruptive cyber attacks, businesses need cyber insurance to help indemnify the loss of business, reputation, and to provide services to those breached. Cyber insurance offers the potential for extremely large losses that admitted carriers tend to avoid. Surplus lines companies are more willing to write reasonably high loss limits on these policies. Ironically, the issue with cyber liability coverage to date is a lack of data. Pricing this risk is incredibly difficult due to small sample sizes, reporting bias, lack of insurance specific data, and no†¦show more content†¦Rebuilding consumer trust after a cyber breach is crucial, which is why many companies offer free credit monitoring and identity theft monitoring. Insurers are taking a more active role in risk management with cyber lines than other lines. AIG, the largest writer of cyber policies, has strategic partnerships with IBM and cybersecurity companies to help their insured population understand their risks and how to best limit them (AIG). This active step in limiting insured risk is similar to health insurers using activity monitors to incentivize active lifestyles. Cyber policies are now mainly written as stand-alone product, allowing for more customization to fit the needs of businesses seeking the coverage. Common coverages include: loss of business income, extortion, corporate data risk, property coverage, and costs relating to reporting cyber breaches including legal fees. Insurers are wary of the loss potential, as such â€Å"many insurers are also setting limits below the levels sought by their clients† and imposing â€Å"restrictive exclusions and conditions† (O’Hearn 5). The combination of tight underwriting criteria, low policy limits, and high cost of coverage inhibits the desirability of cyber insurance, yet this class is growing sharply. Risks With cyber risk, the possibility of large losses is high. According to a NetDiligence study, the median cyber claimShow MoreRelatedTechnological Innovations Are Transforming Almost All Industry1267 Words   |  6 PagesTechnological innovations are transforming almost all industry sectors today including insurance. The primary aim of insurance sector is profitable growth and the use of innovative technologies is one of the most effective ways to enable then achieve this goal. However, many insurance organizations are challenged to keep up with the rapid evolution of technology. Although new technologies are critical for businesses in insurance industry, implementing them require huge capital and resources. According to GreenRead MoreThe Prospect And Challenges Of Cyber Security Insurance922 Words   |  4 Pages2.0 Introduction This chapter presents the prospect and challenges of cyber security insurance among It practitioners in the United Kingdom based on the literature that had been reviewed in the process of writing this paper. This chapter will draw upon results of earlier studies and reports to provide a theoretical framework to answer the research questions of the paper. 2.1. Cyber security and its importance to the modern lives In line with technological advances and the evolution of the internetRead MoreCyber Security And Cyber Threats Essay1510 Words   |  7 Pageshas been confronting issues of cyber-attacks to such an extent that majority of the patients feel every moment that they are at great risk and thus their treatment processes suffer a lot.(Hacking Healthcare IT in 2016) The small sized clinics do not have many resources to enhance their information security systems. Even the large sized enterprises are vulnerable to the cyber threats. The White House had declared that it would increase opportunities to tackle the cyber threats in every sphere, but theRead MoreThe Importance Of Decision Support Strategy1706 Words   |  7 PagesA few researchers also did research into having decision support approaches for cyber security investment. When investing in cyber security assets, information security administrators have to obey operational decision-making strategies. The researchers refer to this as à ¢â‚¬Å"the cyber security investment challenge†. In this paper, they analyze three potential decision support methodologies that security managers can use to be able to perform this challenge. They considered methods based on game theoryRead MoreThe United States Healthcare System1742 Words   |  7 Pagesoverall personal data security as a whole. 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Our portable devices may store our sensitive information such as credit card number, banking info. Latest devicesRead MoreShould The Dental Community Care About Cyber Security? Essay719 Words   |  3 PagesCOURSE TITLE: CYBER TBD Reference Manual Table of Contents – To be developed Section 1. Overview of Current Cyber Security Threats Why should the Dental Community Care about Cyber Security? Imagine this: A virtual intruder, like Tony Soprano, quietly downloads countless patient files containing private medical information — names, procedures, medications, related claims data — which are then sold and resold across the globe. Or imagine that a few laptops containing much of the same type of dataRead MoreCyber Attacks And Physical Damage1279 Words   |  6 Pages Cyber-Attacks and Physical Damage Name Course details Supervisor Institution Date â€Æ' Abstract The internet is considered to be one of the best things to have been invented in the world. 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Students who use social media had an average GPA of 3.06 while nonusersRead MoreHow Online Business And Communication Is An Indispensable Part Of Today s Merging Era Essay1650 Words   |  7 Pagesborders but huge emphasis is laid to secure the countries from computer networking. The impact of online business and communication is an indispensable part of today’s merging era. Unlike traditional wars of using military, weapons and air campaigns; cyber war is more fearful to civilians as it threatens their peace without even been seen. It is quite challenging to identify the ghost in wires, it can be a person, a group of people or it can be a nation behind this intrusion. Former director of the

Friday, December 13, 2019

Pseudomonas Aeruginosa and Nosocomial Infections Free Essays

Bielecki et al. Research Paper Pseudomonas aeruginosa is a Gram-negative bacteria, particularly known for causing nosocomial infections (1). As a pathogen, it effectively causes disease by acquiring resistance to antibiotics that would otherwise inhibit growth (2). We will write a custom essay sample on Pseudomonas Aeruginosa and Nosocomial Infections or any similar topic only for you Order Now Reported rates of infection range from 0. 6 to 32% across various clinical environments because Pseudomonas aeruginosa has gained multi-drug resistance (2). Certain strains of Pseudomonas aeruginosa treated with gamma rays can break down the hydrocarbons in crude oil and are thus useful in cleaning up oil spills (3). The genome of Pseudomonas aeruginosa is 6. 3 million base pairs long, which is the largest bacterial genome to be sequenced (4). It contains about 5,570 open reading frames (4). Argyrin is a naturally synthesized antibiotic peptide extracted from myxobacteria (1). It has cytotoxic properties, suppresses the immune system, and is a highly active antibiotic used against Pseudomonas strains (1). Figure 1. Argyrin A structure. Bielecki et al chose to isolate these resistant clones in order to observe the mechanisms by which the P. eruoginosa acquires resistance to Argyrin A within the fusA1 gene (1). They isolated these clones by growing Pseudomonas aeruginosa strains on agar that contained Argyrin A (1). After incubation, the colonies that formed were able to grow in the presence of argyrin; these colonies were then streaked onto plates with Argyrin A again to ensure accuracy of obtaining resistant strains (1). A point mutation is an alteration of one base pair within a DNA sequence (5) . The point mutations, which caused changes in the amino acid sequence within the fusA1 gene, were different among the six isolates (1). They might have conferred resistance because the mutations caused the same impact on the resulting protein (1). The gene was identified by sequencing the whole genome of Pseudomonas aeruginosa strains with the bacterial target of Argyrin A, which showed mutations within fusA1 that encode for the elongation factor EF-G in resistant strains of Pseudomonas aeruginosa (1). The diagram below illustrates the process of elongation during the translational phase in EF-G along with EF-Tu (12). Figure 2. Elongation during ribosome-catalyzed translation (12). Bielecki et al confirmed the identity of the gene by using genetic maps. This required sequencing the resistant strain a second time to make a reference strain to compare the genes at a specific loci (1). Adding a mutation into the sensitive Pseudomonas aeruginosa strain demonstrated a resistance phenotype (1). Surface plasmon resonance is a lab technique that involves aiming a beam of light at a thin metal sheet, which catalyzes a reactio n by causing movement in the molecules behind the metal sheet (6). SPR was useful in this experiment because it confirmed that fusA1 is the target gene for Argyrin A, rather than fusidic acid, the antibiotic previously recognized (1). A heterologous protein, or a heterologue, is a protein that differs in structure and function relative to a given protein; not all proteins with different amino acid sequence necessarily differ in function (7). N-terminal His6-tags were fused to the fusA1 genes before undergoing the SPR experiments, causing the production of heterologous proteins in relation to the original fusA1 (1). According to Bielecki et al, the SPR procedures supported that Argyrin A binds to fusA1 by the resulting KD value (1). This shows that Argyrin A has a target on the heterologous protein (1). It is important to compare the variations made in the mutations because the other bacteria may have a different sequence that can still achieve resistance (1). It cannot be assumed that all bacterial strains will be identically resistant or sensitive because they all contain differences in their genomes (1). By mapping the mutated genes, the authors found the locations of the mutations in different domains (1). They deduced that the mutations exhibiting resistance to Argyrin A in Pseudomonas aeruginosa are found on opposite sides of the domain, despite the fact that most mutations involving fusidic acid and Argyrin A are located on the same side of the domain (1). This shows that the binding sites for fusidic acid and Argyrin A must be independent of each other (1). Both fusA1 and the second gene, fusA2, encode for the elongation factor EF-G (1). The fusA2 gene was expressed 30 times less in the strains of Pseudomonas aeruginosa than in the fusA1 gene, as shown by RNA sequencing (1). Homology modeling uses the model of a target protein to produce an estimated structure of a homologous template protein (8). After creating a homology model of Argyrin A’s protein structure, Bielecki et al concluded that it â€Å"most likely binds to a site distinct from that of fusidic acid, indicating a new mode of protein biosynthesis inhibition by Argyrin A† (11). Multi-drug resistant pathogens pose a very big risk on the world because they can easily mutate their genomes to adopt resistance to a given antibiotic and persist in causing harmful diseases (1). The authors used MDR clinic isolates in order to observe the mechanisms by which these pathogens mutate to build resistance to Argyrin. The fact that eleven of the twelve isolates showed sensitivity to Argyrin suggests that Argyrin is a useful antibiotic in preventing infections by Pseudomonas aeruginosa (1). There are other factors besides the uptake and export of Argyrin that affect Pseudomonas aeruginosa’s sensitivity to Argyrin, such as efflux pumps (1); however, the uptake and export of Argyrin in other bacteria does play a role in its sensitivity (9). A proteasome is a hollow protein complex with active sites that break down proteins by proteolysis (10). The degraded peptides that are produced can be used for other functions in the cell (10). Argyrin A is a factor used to inhibit proteasome function, yet there is no distinct evidence that Argyrin A binds to the site on the proteasome (1). This paper is important because it analyzes the resistance and sensitivity to Argyrin A in various strains of Pseudomonas aeruginosa. This bacteria has been a leading cause in nosocomial infections, so it is important to determine which antibiotics best work to stop the spread of disease (1). About ten percent of patients in hospitals across the United States obtain a significant nosocomial infection (13). Although there are effective methods to prevent the spread of pathogens in clinical environments (13), it is important to study how bacteria acquire resistance, so that scientists can develop ways to inhibit the spread of nosocomial infections by multi-drug resistant pathogens. Bibliography Bielecki, P. , Lukat, P. , Husecken, K. , Dotsch, A. , Steinmetz, H. , Hartmann, R. W. , Muller, R. , and Houssler, S. (2012) Mutation in elongation factor G confers resistance to the antibiotic Argyrin in the opportunistic pathogen Pseudomonas aeruginosa. Chembiochem. 13, 2339-2345. Obritsch, M. D. , Fish, D. N. , MacLaren, R. , and Jung, R. (2005) Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment options. Pharmacotherapy. 25, 1353-1364. Iqbal, S. , Khalid, Z. M. and Malik, K. A. (1995) Enhanced biodegradation and emulsification of crude oil and hyperproduction of biosurfactants by a gamma ray-induced mutant of Pseudomonas aeruginosa. Lett. Appl. Microbiol. 21,  176–179. C. K. Stover, X. Q. Pham, A. L. Erwin, S. D. Mizoguchi, P. Warrener, M. J. Hickey, F. S. L. Brinkman, W. O. Hufnagle, D. J. Kowalik, et al. (2000) Complete genome sequence of Pseudomonas aeruginosa PAO1, and opportunistic pathogen. Nature. 406, 959-964. Encyclopedia Britannica Online. Point mutation. Accessed 17 Oct. 2012 http://www. britannica. om/EBchecked/topic/54744/point-mutation Manfield, I. (2009) Biacore surface plasmon resonance. Univ. of Leeds, Astbury Centre for Structural Molecular Biology. Accessed 18 Oct. 2012 http://www. astbury. leeds. ac. uk/facil/SPR/spr_intro2004. htm Jackson, J. H. (1999) Terminologies for gene and protein similarity. Michigan State Univ. , Dept. of Microbiology. Accessed 19 Oct. 2012 https://www. msu. edu/~jhjacksn/Reports/similarity. htm Beva n, D. R. (2003) Homology modeling. Virginia Tech, Dept. of Biochemistry. Accessed on 19 Oct. 012 http://www. biochem. vt. edu/modeling/homology. html Sasse, F. , Steinmetz, H. , Schupp, T. , Petersen, F. , Memmert, K. , Hofmann, H. , Heusser, C. , Brinkmann, V. , von Matt, P. , Hofle, G. , and Reichenbach, H. (2002) Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties. J. Antiobiot. 55, 543-551. Rape, M. , and Jentsch, S. (2002) Taking a bite: proteasomal protein processing. Nat. Cell Biol. 4, 113-116. Bielecki, P. , Lukat, P. , Husecken, K. , Dotsch, A. Steinmetz, H. , Hartmann, R. W. , Muller, R. , and Houssler, S. (2012) Mutation in elongation factor G confers resistance to the antibiotic Argyrin in the opportunistic pathogen Pseudomonas aeruginosa. Chembiochem. 13, 2340. Simonovic, M. and Steitz, T. A. (2009) A structural view on the mechanism of the ribosome-catalyzed peptide bond formation. BBA Gene Reg. Mech. 1789, 612-623. Abedon, S. T. (2009) Nosocomial infections. Ohio State University. Accessed on 27 Oct. 2012 http://www. mansfield. ohio-state. edu/~sabedon/biol2053. htm How to cite Pseudomonas Aeruginosa and Nosocomial Infections, Essay examples